For research use only. Not for therapeutic Use.
CXCR2-IN-2（Cat No.:I014812）is a potent and selective small-molecule inhibitor of CXCR2, a chemokine receptor implicated in neutrophil recruitment, angiogenesis, and tumor progression. By blocking CXCR2-mediated signaling, this compound suppresses inflammatory responses and reduces tumor-associated inflammation, making it a valuable agent in studying cancer biology and immunology. CXCR2-IN-2 has shown promise in preclinical models of inflammatory diseases, including arthritis and chronic obstructive pulmonary disease, as well as in tumor microenvironment modulation. Its specificity provides a powerful tool for dissecting chemokine-driven pathways in disease development and therapeutic research.
| CAS Number | 1838123-21-9 |
| Synonyms | 1-[4-chloro-2-hydroxy-3-[(3S)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]urea |
| Molecular Formula | C18H23ClN2O5S |
| Purity | ≥95% |
| IUPAC Name | 1-[4-chloro-2-hydroxy-3-[(3S)-3-methyloxolan-3-yl]sulfonylphenyl]-3-[(1R)-2-methylcyclopent-2-en-1-yl]urea |
| InChI | InChI=1S/C18H23ClN2O5S/c1-11-4-3-5-13(11)20-17(23)21-14-7-6-12(19)16(15(14)22)27(24,25)18(2)8-9-26-10-18/h4,6-7,13,22H,3,5,8-10H2,1-2H3,(H2,20,21,23)/t13-,18+/m1/s1 |
| InChIKey | DNXKACKCTLURQN-ACJLOTCBSA-N |
| SMILES | CC1=CCC[C@H]1NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)[C@]3(CCOC3)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
