CW 008

• CAT Number: I006325
• CAS Number: 1134613-19-6
• Molecular Formula: C21H14F2N6O2
• Molecular Weight: 420.37
• Purity: ≥95%
• Synonyms: 4-fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
• InChI: InChI=1S/C21H14F2N6O2/c1-31-13-6-7-29-17(8-13)15(10-24-29)18-16(23)9-14-19(25-18)27-28-20(14)26-21(30)11-2-4-12(22)5-3-11/h2-10H,1H3,(H2,25,26,27,28,30)
• InChIKey: KCIMKTNQCUDTFI-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=NN2C=C1)C3=C(C=C4C(=N3)NN=C4NC(=O)C5=CC=C(C=C5)F)F

CW 008(CAT: I006325) is a pyrazole-pyridine derivative and a potent agonist of the cAMP/PKA/CREB signaling pathway, known for its role in stem cell differentiation and bone regeneration. It promotes osteogenic differentiation of human mesenchymal stem cells (hMSCs) and enhances bone formation in ovariectomized mouse models, suggesting strong therapeutic potential for osteoporosis and skeletal tissue engineering. CW 008 exerts its effects by activating CREB phosphorylation and suppressing leptin secretion, thus modulating both intracellular signaling and endocrine factors involved in bone metabolism. This compound is ideal for studies on osteogenesis, stem cell-based therapies, and bone anabolic drug development.