CVT-11127

• CAT Number: R040312
• CAS Number: 1018674-83-3
• Molecular Formula: C25H23Cl2N5O3
• Molecular Weight: 512.39
• Purity: ≥95%
• Synonyms: N-[2-[6-[(3,4-dichlorophenyl)methylamino]-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4-yl]ethyl]acetamide
• InChI: InChI=1S/C25H23Cl2N5O3/c1-15(33)28-11-12-32-24-21(30-23(25(32)34)17-4-6-18(35-2)7-5-17)9-10-22(31-24)29-14-16-3-8-19(26)20(27)13-16/h3-10,13H,11-12,14H2,1-2H3,(H,28,33)(H,29,31)
• InChIKey: PVTIQVJHZDSETN-UHFFFAOYSA-N
• SMILES: CC(=O)NCCN1C2=C(C=CC(=N2)NCC3=CC(=C(C=C3)Cl)Cl)N=C(C1=O)C4=CC=C(C=C4)OC

CVT-11127（Cat No.:R040312）is a potent and selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanine nucleotides. By blocking IMPDH activity, CVT-11127 effectively reduces lymphocyte proliferation, making it a valuable tool in immunosuppression and anti-inflammatory research. It has demonstrated potential in preventing graft rejection and treating autoimmune diseases. Additionally, CVT-11127 aids in exploring nucleotide metabolism and its impact on immune cell function. Its specificity and mechanism of action support its use in studying therapeutic strategies targeting hyperactive immune responses and related pathological conditions.