For research use only. Not for therapeutic Use.
CVN424（Cat No.:I044556）is a highly selective GPR6 inverse agonist developed for the treatment of Parkinson’s disease. GPR6 is an orphan G protein–coupled receptor predominantly expressed in the striatum, a brain region involved in motor control. By inhibiting GPR6 activity, CVN424 enhances dopaminergic signaling without directly targeting dopamine receptors, potentially reducing motor symptoms while avoiding common side effects of traditional dopaminergic therapies. Preclinical and early clinical studies have shown that CVN424 improves motor function and is well tolerated. It represents a novel, non-dopaminergic approach to managing Parkinson’s disease.
| CAS Number | 2254706-21-1 |
| Synonyms | 1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone |
| Molecular Formula | C24H29F2N5O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone |
| InChI | InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m1/s1 |
| InChIKey | HSWVJQBEXRKOBZ-QGZVFWFLSA-N |
| SMILES | CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
