Cu(II)-Elesclomol

• CAT Number: I040560
• CAS Number: 1224195-72-5
• Molecular Formula: C19H18CuN4O2S2
• Molecular Weight: 462.05
• Purity: ≥95%
• IUPAC Name: copper;[benzenecarbonothioyl(methyl)amino]-[3-[benzenecarbonothioyl(methyl)amino]azanidyl-3-oxopropanoyl]azanide
• InChI: InChI=1S/C19H20N4O2S2.Cu/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15;/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25);/p-2
• InChIKey: MGWYEXXXVPOYFG-UHFFFAOYSA-L
• SMILES: CN(/N=C(\[O-])/C/C(=N/N(C(=S)C1=CC=CC=C1)C)/[O-])C(=S)C2=CC=CC=C2.[Cu]

Cu(II)-Elesclomol(CAT: I040560) is a copper–drug complex formed by Elesclomol and divalent copper ions (Cu²⁺), known for its ability to induce oxidative stress in cancer cells. This compound exploits the elevated reactive oxygen species (ROS) vulnerability in tumor cells by delivering copper directly into mitochondria, where redox cycling generates cytotoxic ROS. Cu(II)-Elesclomol has shown promise in targeting cancer cells with low antioxidant capacity, particularly in melanoma and other oxidative stress-sensitive malignancies. It is a valuable agent for studying redox biology, mitochondrial metabolism, and copper homeostasis in cancer research. Ideal for in vitro and preclinical studies on redox-based anticancer strategies.