For research use only. Not for therapeutic Use.
CU06-1004 (Sac-1004)(CAT: I040575) is an orally active small molecule that targets endothelial dysfunction. It exerts its therapeutic effects by inhibiting vascular hyperpermeability and suppressing inflammation, thereby restoring endothelial barrier integrity. CU06-1004 has demonstrated strong efficacy in reducing vascular leakage and inflammation across multiple animal models, including those of diabetic retinopathy, stroke, cancer, and inflammatory bowel disease. Additionally, CU06-1004 significantly improves liver pathology in a CDAA-induced mouse model of nonalcoholic steatohepatitis (NASH) and enhances cardiac function. Its multi-organ protective effects position it as a promising candidate for treating chronic inflammatory and vascular-related diseases in preclinical research settings
| CAS Number | 1296734-08-1 |
| Synonyms | methyl (E)-6-[(3S,8S,9S,10R,13S,14S,17R)-3-[[(2R,3S)-3-acetyloxy-2-(acetyloxymethyl)-3,6-dihydro-2H-pyran-6-yl]oxy]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-enoate |
| Molecular Formula | C37H54O8 |
| Purity | ≥95% |
| IUPAC Name | methyl (E)-6-[(3S,8S,9S,10R,13S,14S,17R)-3-[[(2R,3S)-3-acetyloxy-2-(acetyloxymethyl)-3,6-dihydro-2H-pyran-6-yl]oxy]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-enoate |
| InChI | InChI=1S/C37H54O8/c1-23(9-7-8-10-34(40)41-6)29-13-14-30-28-12-11-26-21-27(17-19-36(26,4)31(28)18-20-37(29,30)5)44-35-16-15-32(43-25(3)39)33(45-35)22-42-24(2)38/h9,11,15-16,27-33,35H,7-8,10,12-14,17-22H2,1-6H3/b23-9+/t27-,28-,29+,30-,31-,32-,33+,35?,36-,37+/m0/s1 |
| InChIKey | HYMSACOZWCUWKA-QGRUFDIBSA-N |
| SMILES | C/C(=C\CCCC(=O)OC)/[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC5C=C[C@@H]([C@H](O5)COC(=O)C)OC(=O)C)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
