For research use only. Not for therapeutic Use.
CTX-712（Cat No.:I044032）is a selective inhibitor of cyclin-dependent kinases CDK7, CDK12, and CDK13, enzymes critical for transcriptional regulation and cell cycle progression. By targeting these kinases, CTX-712 disrupts phosphorylation of the RNA polymerase II C-terminal domain, thereby impairing transcription elongation and DNA damage response pathways. This mechanism makes it particularly valuable in cancer research, especially for tumors dependent on transcriptional addiction, such as MYC-driven or DNA repair-deficient cancers. CTX-712 offers a promising tool for investigating transcription-targeted therapies and understanding CDK-mediated regulation in oncogenic and stress-response pathways.
| CAS Number | 2144751-78-8 |
| Synonyms | 2-[(1R)-1-fluoroethyl]-5-[[6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methylimidazo[4,5-b]pyridin-1-yl]methyl]-1,3,4-oxadiazole |
| Molecular Formula | C19H17FN8O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[(1R)-1-fluoroethyl]-5-[[6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methylimidazo[4,5-b]pyridin-1-yl]methyl]-1,3,4-oxadiazole |
| InChI | InChI=1S/C19H17FN8O2/c1-10(20)18-26-25-15(30-18)8-27-11(2)24-17-14(27)6-12(7-21-17)13-4-5-28-16(13)19(29-3)22-9-23-28/h4-7,9-10H,8H2,1-3H3/t10-/m1/s1 |
| InChIKey | OENNTZBJPRRGFL-SNVBAGLBSA-N |
| SMILES | CC1=NC2=C(N1CC3=NN=C(O3)[C@@H](C)F)C=C(C=N2)C4=C5C(=NC=NN5C=C4)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
