CTCE-0214

• CAT Number: I042539
• CAS Number: 577782-52-6
• Molecular Formula: C170H254N44O40
• Molecular Weight: 3554.11
• Purity: ≥95%

CTCE-0214 (Cat No.: I042539) is a synthetic peptide and potent agonist of the chemokine receptor CXCR4, a receptor involved in immune cell trafficking, tissue repair, and inflammation. Unlike natural ligands like CXCL12 (SDF-1), CTCE-0214 is engineered for enhanced stability and bioavailability. It has shown promise in preclinical studies for reducing inflammation, modulating immune responses, and promoting tissue regeneration. CTCE-0214 is particularly studied in models of sepsis, myocardial infarction, and autoimmune disorders, offering potential therapeutic value in diseases involving dysregulated CXCR4 signaling.

Reference

[1]. Fan H, et al. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35(1):130-7.
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[2]. Faber A, et al. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J Biomed Biotechnol. 2007;2007(3):26065.
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[3]. Li K, et al. Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice. Stem Cells. 2006 Jan;24(1):55-64.
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