For research use only. Not for therapeutic Use.
CSF1R-IN-3（Cat No.:I044090）is a potent and selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), a receptor tyrosine kinase crucial for the regulation of monocyte and macrophage survival, proliferation, and differentiation. By blocking CSF1R signaling, CSF1R-IN-3 effectively suppresses tumor-associated macrophages (TAMs) and modulates the tumor immune microenvironment, making it highly valuable in cancer immunotherapy research. It is also used to study inflammatory diseases, such as rheumatoid arthritis and neuroinflammation, where macrophage activity is dysregulated. CSF1R-IN-3 supports investigations into myeloid cell biology and the development of immune-modulating therapeutic strategies.
| CAS Number | 2760584-90-3 |
| Synonyms | N-[5-[(Z)-[6-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-2-(4-methylpiperazin-1-yl)acetamide |
| Molecular Formula | C30H38N8O4 |
| Purity | ≥95% |
| IUPAC Name | N-[5-[(Z)-[6-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-2-(4-methylpiperazin-1-yl)acetamide |
| InChI | InChI=1S/C30H38N8O4/c1-17-22(31-18(2)27(17)35-26(39)16-38-11-9-37(6)10-12-38)14-21-20-8-7-19(13-23(20)33-28(21)40)32-29(41)34-25-15-24(42-36-25)30(3,4)5/h7-8,13-15,31H,9-12,16H2,1-6H3,(H,33,40)(H,35,39)(H2,32,34,36,41)/b21-14- |
| InChIKey | YLKFFTVAKILRBN-STZFKDTASA-N |
| SMILES | CC1=C(NC(=C1NC(=O)CN2CCN(CC2)C)C)/C=C\3/C4=C(C=C(C=C4)NC(=O)NC5=NOC(=C5)C(C)(C)C)NC3=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
