For research use only. Not for therapeutic Use.
CRT0273750 (Cat No.: I025224) is a small-molecule inhibitor identified for its activity against the Wnt/β-catenin signaling pathway, a critical regulator of cell proliferation, differentiation, and survival. By suppressing aberrant Wnt signaling, CRT0273750 helps block transcriptional programs often hijacked in cancer and other proliferative disorders. It is mainly used in preclinical research to investigate the therapeutic potential of Wnt pathway inhibition in oncology and regenerative medicine. As a targeted chemical probe, CRT0273750 provides valuable insights into pathway modulation and downstream gene regulation.
| CAS Number | 1979939-16-6 |
| Synonyms | N-[(1S)-1-(4-chlorophenyl)ethyl]-3-[3-[[4-(trifluoromethoxy)phenyl]methyl]imidazo[4,5-b]pyridin-2-yl]propanamide |
| Molecular Formula | C25H22ClF3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H22ClF3N4O2/c1-16(18-6-8-19(26)9-7-18)31-23(34)13-12-22-32-21-3-2-14-30-24(21)33(22)15-17-4-10-20(11-5-17)35-25(27,28)29/h2-11,14,16H,12-13,15H2,1H3,(H,31,34)/t16-/m0/s1 |
| InChIKey | HXYXHSDYBDFOFO-INIZCTEOSA-N |
| SMILES | CC(C1=CC=C(C=C1)Cl)NC(=O)CCC2=NC3=C(N2CC4=CC=C(C=C4)OC(F)(F)F)N=CC=C3 |
| Reference | [1]. Shah P, et al. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorg Med Chem Lett. 2016;26(22):5403-5410. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
