For research use only. Not for therapeutic Use.
CRT0066854（Cat No.:I011884）is a potent and selective inhibitor of CHK1 (Checkpoint Kinase 1), a serine/threonine kinase involved in DNA damage response and cell cycle regulation. By inhibiting CHK1, CRT0066854 impairs cell cycle arrest and DNA repair mechanisms, sensitizing cancer cells to replication stress and genotoxic agents. It is particularly useful in studying tumor cell vulnerability, especially in p53-deficient or DNA repair-deficient models. CRT0066854 is widely applied in oncology research to explore combination therapies with chemotherapy or radiation. For investigational use in laboratory settings only; not for human or veterinary application.
| CAS Number | 1438881-19-6 |
| Synonyms | (2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine |
| Molecular Formula | C24H25N5S |
| Purity | ≥95% |
| IUPAC Name | (2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine |
| InChI | InChI=1S/C24H25N5S/c25-18(14-16-6-2-1-3-7-16)15-27-23-21-19-8-4-5-9-20(19)30-24(21)29-22(28-23)17-10-12-26-13-11-17/h1-3,6-7,10-13,18H,4-5,8-9,14-15,25H2,(H,27,28,29)/t18-/m0/s1 |
| InChIKey | NRHASZRDWOUMFD-SFHVURJKSA-N |
| SMILES | C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NC[C@H](CC5=CC=CC=C5)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
