CRT0066854 hydrochloride

• CAT Number: I015574
• CAS Number: 2250019-91-9
• Molecular Formula: C24H26ClN5S
• Molecular Weight: 452.01
• Purity: ≥95%
• Synonyms: (2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine;hydrochloride
• IUPAC Name: (2S)-3-phenyl-1-N-(2-pyridin-4-yl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)propane-1,2-diamine;dihydrochloride
• InChI: InChI=1S/C24H25N5S.2ClH/c25-18(14-16-6-2-1-3-7-16)15-27-23-21-19-8-4-5-9-20(19)30-24(21)29-22(28-23)17-10-12-26-13-11-17;;/h1-3,6-7,10-13,18H,4-5,8-9,14-15,25H2,(H,27,28,29);2*1H/t18-;;/m0../s1
• InChIKey: NYUVOWXZRBZQBA-NTEVMMBTSA-N
• SMILES: C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NC[C@H](CC5=CC=CC=C5)N.Cl.Cl

CRT0066854 hydrochloride（Cat No.:I015574）is a potent small-molecule inhibitor of checkpoint kinase 1 (Chk1), a key regulator of DNA damage response and cell cycle progression. By blocking Chk1, it disrupts tumor cell ability to repair DNA damage, enhancing sensitivity to genotoxic stress and chemotherapy. This compound has been studied in cancer research for its potential to overcome resistance and promote apoptotic cell death in rapidly dividing cells. The hydrochloride salt form improves solubility and handling, making CRT0066854 a valuable probe for exploring DNA repair pathways and therapeutic strategies in oncology.