CRT-0105446

• CAT Number: I025222
• CAS Number: 1661846-05-4
• Molecular Formula: C20H18F3N3O2S
• Molecular Weight: 421.44
• Purity: ≥95%

CRT 0105446 (compound 22d) is a potent inhibitor of LIMK1 with an IC50 of 8 nM. It can inhibit the growth of MCF-7 breast cancer cells and the invasion of MDA-MB-231 cells by reducing the expression of phosphorylated cofilin.

Reference

[1] Charles MD, et al. J Med Chem. 2015;58(20):8309-8313.
[2] Zhang M, et al. J Cell Mol Med. 2021;25(12):5560-5571.