For research use only. Not for therapeutic Use.
CRBN-6-5-5-VHL（Cat No.:I044498）is a heterobifunctional PROTAC (proteolysis-targeting chimera) linker that connects cereblon (CRBN) and von Hippel–Lindau (VHL) E3 ligase ligands via a 6-5-5 (carbon-carbon-carbon) alkyl chain architecture. This unique dual-recruitment design enables the simultaneous engagement of two E3 ligases, potentially enhancing the ubiquitination and degradation of target proteins. The molecule serves as a chemical biology tool for studying cooperative or competitive E3 ligase interactions and optimizing degradation efficiency. CRBN-6-5-5-VHL is valuable for exploring novel degrader architectures in drug discovery and understanding mechanisms of targeted protein degradation.
| CAS Number | 2362575-45-7 |
| Synonyms | (2S,4R)-1-[(2S)-2-[5-[5-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexoxy]pentoxy]pentanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C51H69N7O10S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[5-[5-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexoxy]pentoxy]pentanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C51H69N7O10S/c1-33-44(69-32-54-33)35-20-18-34(19-21-35)30-53-46(62)40-29-36(59)31-57(40)50(66)45(51(2,3)4)55-41(60)17-8-13-28-68-27-12-7-11-26-67-25-10-6-5-9-24-52-38-16-14-15-37-43(38)49(65)58(48(37)64)39-22-23-42(61)56-47(39)63/h14-16,18-21,32,36,39-40,45,52,59H,5-13,17,22-31H2,1-4H3,(H,53,62)(H,55,60)(H,56,61,63)/t36-,39?,40+,45-/m1/s1 |
| InChIKey | LIMCHOLAKDUZDS-XARBDFOFSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCOCCCCCOCCCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
