For research use only. Not for therapeutic Use.
CRAMP (Cathelin-Related Antimicrobial Peptide)(CAT: I040408) is the murine homolog of human LL-37, belonging to the cathelicidin family of host defense peptides. Expressed in various epithelial and immune cells, CRAMP exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. It also plays critical roles in modulating immune responses, including chemotaxis, cytokine release, and wound healing. CRAMP is widely used in research on innate immunity, inflammation, and microbiome-host interactions in murine models. Its synthetic form is supplied at high purity and is ideal for investigating antimicrobial mechanisms, immune modulation, and therapeutic peptide development in preclinical immunology and infectious disease studies.
| CAS Number | 376364-36-2 |
| Molecular Formula | C178H302N50O46 |
| Purity | ≥95% |
| IUPAC Name | (2S)-5-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-5-amino-2-[[2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]acetyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acid |
| InChI | InChI=1S/C178H302N50O46/c1-17-102(14)146(224-160(256)112(54-31-39-79-184)207-150(246)108(50-27-35-75-180)210-164(260)124(86-98(6)7)217-152(248)109(51-28-36-76-181)205-156(252)118(65-72-143(241)242)202-141(238)96-199-173(269)147(103(15)18-2)225-161(257)113(55-32-40-80-185)209-157(253)117(64-71-142(239)240)201-139(236)94-196-138(235)93-197-149(245)107(49-26-34-74-179)204-151(247)115(57-42-82-195-178(193)194)211-165(261)125(87-99(8)9)219-163(259)123(85-97(4)5)203-137(234)92-187)172(268)198-95-140(237)200-116(60-67-132(188)229)155(251)208-114(56-33-41-81-186)162(258)226-148(104(16)19-3)174(270)214-111(53-30-38-78-183)154(250)222-129(91-136(192)233)168(264)221-128(90-106-47-24-21-25-48-106)167(263)220-127(89-105-45-22-20-23-46-105)166(262)212-119(61-68-133(189)230)158(254)206-110(52-29-37-77-182)153(249)218-126(88-100(10)11)169(265)223-145(101(12)13)176(272)228-84-44-59-131(228)171(267)215-121(62-69-134(190)231)175(271)227-83-43-58-130(227)170(266)213-120(66-73-144(243)244)159(255)216-122(177(273)274)63-70-135(191)232/h20-25,45-48,97-104,107-131,145-148H,17-19,26-44,49-96,179-187H2,1-16H3,(H2,188,229)(H2,189,230)(H2,190,231)(H2,191,232)(H2,192,233)(H,196,235)(H,197,245)(H,198,268)(H,199,269)(H,200,237)(H,201,236)(H,202,238)(H,203,234)(H,204,247)(H,205,252)(H,206,254)(H,207,246)(H,208,251)(H,209,253)(H,210,260)(H,211,261)(H,212,262)(H,213,266)(H,214,270)(H,215,267)(H,216,255)(H,217,248)(H,218,249)(H,219,259)(H,220,263)(H,221,264)(H,222,250)(H,223,265)(H,224,256)(H,225,257)(H,226,258)(H,239,240)(H,241,242)(H,243,244)(H,273,274)(H4,193,194,195)/t102-,103-,104-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,145-,146-,147-,148-/m0/s1 |
| InChIKey | QXPUNNLAJZEETG-HDZBAWFTSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN |
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