For research use only. Not for therapeutic Use.
CR-1-30-B（Cat No.:I044494）is a potent and selective inhibitor of the STAT3 (Signal Transducer and Activator of Transcription 3) signaling pathway, which plays a critical role in cancer cell survival, proliferation, and immune evasion. By blocking STAT3 phosphorylation and dimerization, CR-1-30-B disrupts the transcription of oncogenic target genes, leading to apoptosis and growth inhibition in various tumor models. It is particularly valuable in cancers where STAT3 is constitutively activated. CR-1-30-B is widely used in preclinical studies to investigate STAT3-driven oncogenesis and evaluate targeted therapeutic strategies in inflammation-associated and drug-resistant cancers.
| CAS Number | 1352914-53-4 |
| Synonyms | (1S,2S,3R,3aS,8bR)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide |
| Molecular Formula | C28H29NO8 |
| Purity | ≥95% |
| IUPAC Name | (1S,2S,3R,3aS,8bR)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide |
| InChI | InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m0/s1 |
| InChIKey | KLSIFOJPWJBRFH-DFEWDZLZSA-N |
| SMILES | COC1=CC=C(C=C1)[C@@]23[C@H]([C@@H]([C@@H]([C@@]2(C4=C(O3)C=C(C=C4OC)OC)O)O)C(=O)NOC)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
