For research use only. Not for therapeutic Use.
CPS2（Cat No.:I045250）is a potent, selective inhibitor of carbamoyl phosphate synthetase 2, the first enzymatic activity of the CAD trifunctional protein involved in de novo pyrimidine biosynthesis. By blocking CPS2, the compound reduces carbamoyl phosphate production, limiting the synthesis of uridine monophosphate (UMP) and downstream nucleotides. This disruption impairs DNA and RNA synthesis, making CPS2 a valuable research tool in studying nucleotide metabolism, cancer cell proliferation, and metabolic regulation. Its specificity and cellular activity support applications in both biochemical assays and cell-based studies targeting pyrimidine biosynthetic pathways for therapeutic development.
| CAS Number | 2756741-90-7 |
| Synonyms | 4-[[5-amino-1-(3-methylthiophene-2-carbonyl)-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]ethyl]benzenesulfonamide |
| Molecular Formula | C38H42N12O10S2 |
| Purity | ≥95% |
| IUPAC Name | 4-[[5-amino-1-(3-methylthiophene-2-carbonyl)-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]ethyl]benzenesulfonamide |
| InChI | InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46) |
| InChIKey | BXCPYBFBMAWDDY-UHFFFAOYSA-N |
| SMILES | CC1=C(SC=C1)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)NCCOCC4=CN(N=N4)CCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
