CPPG

• CAT Number: M033049
• CAS Number: 183364-82-1
• Molecular Formula: C11H14NO5P
• Molecular Weight: 271.21
• Purity: ≥95%
• Synonyms: 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid
• InChI: InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
• InChIKey: IGODGTDUQSMDQU-UHFFFAOYSA-N
• SMILES: C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N

CPPG (RS)-α-Cyclopropyl-4-phosphonophenylglycine (Cat No.: M033049) is a selective antagonist of metabotropic glutamate receptors (mGluRs), particularly mGluR group III subtypes. By inhibiting these receptors, CPPG modulates glutamatergic neurotransmission, making it a valuable pharmacological tool in neuroscience research for studying synaptic plasticity, learning, memory, and neurodegenerative disorders. Its phosphonic acid group enhances receptor binding affinity, while the cyclopropyl moiety contributes to structural rigidity. CPPG is commonly used in electrophysiological and behavioral experiments to explore the functional roles of inhibitory mGluRs in the central nervous system.

Reference

[1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.
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