For research use only. Not for therapeutic Use.
CPL304110 (Cat No.: I045438) is a selective, orally active inhibitor of fibroblast growth factor receptor 1–3 (FGFR1–3) tyrosine kinases, designed to block aberrant FGFR signaling involved in tumor growth, angiogenesis, and survival. By inhibiting FGFR phosphorylation and downstream pathways such as MAPK and PI3K/Akt, CPL304110 suppresses cancer cell proliferation and migration. It is under investigation for the treatment of FGFR-driven malignancies, including urothelial carcinoma and cholangiocarcinoma. CPL304110 is also a valuable research tool for studying FGFR biology and targeted cancer therapy development.
| CAS Number | 1627826-19-0 |
| Synonyms | 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methylpiperazin-1-yl)-1H-benzimidazole |
| Molecular Formula | C25H30N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H30N6O2/c1-30-8-10-31(11-9-30)19-6-7-22-23(15-19)27-25(26-22)24-14-18(28-29-24)5-4-17-12-20(32-2)16-21(13-17)33-3/h6-7,12-16H,4-5,8-11H2,1-3H3,(H,26,27)(H,28,29) |
| InChIKey | QHCGPJPIPKDWAT-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=NNC(=C4)CCC5=CC(=CC(=C5)OC)OC |
| Reference | [1]. Abdellah Yamani, et al. Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3). Eur J Med Chem. 2020 Nov 7;112990. |
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