• CAT Number: I005683
  • CAS Number: 95809-78-2
  • Molecular Formula: C₂₂H₂₈O₂S₂
  • Molecular Weight: 388.59
  • Purity: ≥95%
Inquiry Now

Devimistat ( CPI-613 ) is a lipoate analogue that inhibits mitochondrial enzymes pyruvate dehydrogenase ( PDH ) and α-ketoglutarate dehydrogenase in NCI-H460 cell line and interferes with mitochondrial metabolism in tumor cells. CPI-613 can induce apoptosis of pancreatic cancer cells.

Catalog Number I005683
CAS Number 95809-78-2
Molecular Formula


Purity 95%
Target Dehydrogenase
Solubility 10 mM in DMSO
Storage 2-8°C
IUPAC Name 6,8-bis(benzylsulfanyl)octanoic acid
InChI InChI=1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)

</br>1:Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D/’Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L, Hawkins G, Jin G, Zhang W, Pasche B.Lancet Oncol. 2017 May 8. pii: S1470-2045(17)30314-5. doi: 10.1016/S1470-2045(17)30314-5. [Epub ahead of print] PMID: 28495639 </br>2:A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma. Lycan TW, Pardee TS, Petty WJ, Bonomi M, Alistar A, Lamar ZS, Isom S, Chan MD, Miller AA, Ruiz J.PLoS One. 2016 Oct 12;11(10):e0164244. doi: 10.1371/journal.pone.0164244. eCollection 2016. PMID: 27732654 Free PMC Article</br>3:Translational assessment of mitochondrial dysfunction of pancreatic cancer from in vitro gene microarray and animal efficacy studies, to early clinical studies, via the novel tumor-specific anti-mitochondrial agent, CPI-613. Lee KC, Maturo C, Perera CN, Luddy J, Rodriguez R, Shorr R.Ann Transl Med. 2014 Sep;2(9):91. doi: 10.3978/j.issn.2305-5839.2014.05.08. PMID: 25405166 Free PMC Article</br>4:A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies. Pardee TS, Lee K, Luddy J, Maturo C, Rodriguez R, Isom S, Miller LD, Stadelman KM, Levitan D, Hurd D, Ellis LR, Harrelson R, Manuel M, Dralle S, Lyerly S, Powell BL.Clin Cancer Res. 2014 Oct 15;20(20):5255-64. doi: 10.1158/1078-0432.CCR-14-1019. Epub 2014 Aug 27. PMID: 25165100 Free PMC Article</br>5:Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Lee KC, Shorr R, Rodriguez R, Maturo C, Boteju LW, Sheldon A.Drug Metab Lett. 2011 Aug;5(3):163-82. PMID: 21722089

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!