For research use only. Not for therapeutic Use.
CPI-1612（Cat No.:I015462）is a potent, selective small-molecule inhibitor of CREB-binding protein (CBP) and p300 histone acetyltransferases (HATs). By blocking acetylation of histone and non-histone proteins, it modulates chromatin accessibility and transcriptional regulation. CPI-1612 has shown strong activity in models of hormone-driven cancers, particularly estrogen receptor–positive breast cancer, where CBP/p300 act as critical co-activators. It is also used to investigate epigenetic control of gene expression, tumor progression, and potential combination therapies. As a chemical probe, CPI-1612 provides researchers with a powerful tool to dissect transcriptional and epigenetic mechanisms in disease.
| CAS Number | 2374971-81-8 |
| Synonyms | (2R)-2-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methylpyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide |
| Molecular Formula | C27H26N6O |
| Purity | ≥95% |
| IUPAC Name | (2R)-2-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methylpyrazol-4-yl)pyridin-2-yl]-2-phenylacetamide |
| InChI | InChI=1S/C27H26N6O/c1-19(21-10-8-20(14-28)9-11-21)15-30-26(22-6-4-3-5-7-22)27(34)32-25-13-12-23(16-29-25)24-17-31-33(2)18-24/h3-13,16-19,26,30H,15H2,1-2H3,(H,29,32,34)/t19-,26-/m1/s1 |
| InChIKey | SEDFZSHSBUXKAC-NIYFSFCBSA-N |
| SMILES | C[C@H](CN[C@H](C1=CC=CC=C1)C(=O)NC2=NC=C(C=C2)C3=CN(N=C3)C)C4=CC=C(C=C4)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
