CP-346086

• CAT Number: R055607
• CAS Number: 186390-48-7
• Molecular Formula: C26H22F3N5O
• Molecular Weight: 477.48
• Purity: ≥95%
• Synonyms: N-[2-(1H-1,2,4-triazol-5-ylmethyl)-3,4-dihydro-1H-isoquinolin-6-yl]-2-[4-(trifluoromethyl)phenyl]benzamide
• InChI: InChI=1S/C26H22F3N5O/c27-26(28,29)20-8-5-17(6-9-20)22-3-1-2-4-23(22)25(35)32-21-10-7-19-14-34(12-11-18(19)13-21)15-24-30-16-31-33-24/h1-10,13,16H,11-12,14-15H2,(H,32,35)(H,30,31,33)
• InChIKey: WNDIAFXQKOHFLV-UHFFFAOYSA-N
• SMILES: C1CN(CC2=C1C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)CC5=NC=NN5

CP-346086 (Cat No.: R055607) is a potent and selective inhibitor of microsomal triglyceride transfer protein (MTP), a key enzyme involved in the assembly and secretion of apolipoprotein B–containing lipoproteins such as VLDL and LDL. By blocking MTP activity, CP-346086 reduces plasma triglyceride and cholesterol levels, making it a valuable tool for studying lipid metabolism and cardiovascular disease. It has been investigated in preclinical models as a potential therapeutic for hyperlipidemia and atherosclerosis. CP-346086 is widely used in metabolic and cardiovascular research applications.

Reference

[1]. Chandler CE, et, al. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res. 2003 Oct;44(10):1887-901.
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