For research use only. Not for therapeutic Use.
Cotosudil (Cat No.:I044673) is a selective Rho-associated protein kinase 1 (ROCK1) inhibitor developed primarily for the treatment of glaucoma and ocular hypertension. By inhibiting ROCK1, cotosudil enhances aqueous humor outflow through the trabecular meshwork, thereby lowering intraocular pressure (IOP). Its mechanism also offers potential neuroprotective and anti-fibrotic effects, expanding its therapeutic relevance beyond IOP control. Cotosudil has demonstrated efficacy and tolerability in preclinical and early clinical studies, positioning it as a promising topical agent for managing glaucoma and potentially other ocular diseases involving ROCK-mediated pathways.
| CAS Number | 1258833-31-6 |
| Synonyms | 6-[[(2R)-2-methyl-1,4-diazocan-1-yl]sulfonyl]isoquinoline |
| Molecular Formula | C16H21N3O2S |
| Purity | ≥95% |
| IUPAC Name | 6-[[(2R)-2-methyl-1,4-diazocan-1-yl]sulfonyl]isoquinoline |
| InChI | InChI=1S/C16H21N3O2S/c1-13-11-17-7-2-3-9-19(13)22(20,21)16-5-4-15-12-18-8-6-14(15)10-16/h4-6,8,10,12-13,17H,2-3,7,9,11H2,1H3/t13-/m1/s1 |
| InChIKey | OIJDBECSPSHUGA-CYBMUJFWSA-N |
| SMILES | C[C@@H]1CNCCCCN1S(=O)(=O)C2=CC3=C(C=C2)C=NC=C3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
