Coronaridine

• CAT Number: I045533
• CAS Number: 467-77-6
• Molecular Formula: C21H26N2O2
• Molecular Weight: 338.44
• Purity: ≥95%
• Synonyms: methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate
• InChI: InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14+,19+,21-/m1/s1
• InChIKey: NVVDQMVGALBDGE-PZXGUROGSA-N
• SMILES: CCC1CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC

Coronaridine (Cat No.: I045533) is an indole alkaloid naturally occurring in plants of the Tabernanthe and Voacanga genera, structurally related to ibogaine. It exhibits a range of pharmacological properties, including anti-addictive, antimalarial, antileishmanial, and analgesic effects. Studies suggest coronaridine can modulate neurotransmitter systems, particularly dopaminergic and serotonergic pathways, contributing to its potential in treating substance use disorders. It also shows cytotoxic activity against certain cancer cell lines. As a bioactive natural product, coronaridine serves as both a medicinal lead and a biochemical research tool.

Reference

[1]. Kensuke Ohishi, et al. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3937-40.
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[2]. Hugo R Arias, et al. Coronaridine congeners potentiate GABA A receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109930
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