Coralyne chloride

• CAT Number: I025103
• CAS Number: 38989-38-7
• Molecular Formula: C22H22ClNO4
• Molecular Weight: 399.87
• Purity: ≥95%
• Synonyms: 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride
• InChI: InChI=1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1
• InChIKey: PDYBUYVOPAJLKP-UHFFFAOYSA-M
• SMILES: CC1=C2C=C(C(=CC2=CC3=[N+]1C=CC4=CC(=C(C=C43)OC)OC)OC)OC.[Cl-]

Coralyne chloride (Cat No.: I025103) is a synthetic antimalarial and intercalating agent structurally related to acridine derivatives. It binds strongly to nucleic acids, particularly DNA, and has been widely used to study triplex DNA formation, telomeric structures, and nucleic acid–ligand interactions. Coralyne exhibits antiprotozoal, antimicrobial, and anticancer activities through its ability to disrupt DNA processes and inhibit cell proliferation. In research, it serves as a valuable chemical probe for exploring DNA binding, molecular recognition, and therapeutic development targeting nucleic acid structures.

Reference

[1]. Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.
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[2]. D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91.
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[3]. P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667.
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