COQ7-IN-1

• CAT Number: I045314
• CAS Number: 2579696-72-1
• Molecular Formula: C14H10ClN3O
• Molecular Weight: 271.70
• Purity: ≥95%
• Synonyms: 2-(5-chloropyridin-2-yl)-5-phenyl-1H-pyrazol-3-one
• InChI: InChI=1S/C14H10ClN3O/c15-11-6-7-13(16-9-11)18-14(19)8-12(17-18)10-4-2-1-3-5-10/h1-9,17H
• InChIKey: IRQULQWSSURBFT-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC(=O)N(N2)C3=NC=C(C=C3)Cl

COQ7-IN-1 (Cat No.: I045314) is a selective small-molecule inhibitor of coenzyme Q7 hydroxylase (COQ7), an essential enzyme in the biosynthesis of coenzyme Q (ubiquinone), a key component of the mitochondrial electron transport chain. By targeting COQ7, this compound disrupts mitochondrial respiration and oxidative phosphorylation, making it valuable for studying mitochondrial metabolism and related pathologies. COQ7-IN-1 is used in research to investigate energy homeostasis, neurodegenerative disorders, and cancer metabolism, offering insights into mitochondrial dysfunction and potential avenues for therapeutic intervention.

Reference

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182.
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