For research use only. Not for therapeutic Use.
Copanlisib dihydrochloride(CAT: I014306) is a potent, intravenously administered phosphoinositide 3-kinase (PI3K) inhibitor with activity against multiple isoforms, showing highest potency toward PI3K-α and PI3K-δ. By targeting PI3K signaling, Copanlisib disrupts pathways regulating cell survival, proliferation, and metabolism, making it a valuable compound for oncology research. It has been investigated clinically for the treatment of relapsed follicular lymphoma and other hematological malignancies, where it induces apoptosis and reduces tumor growth. The dihydrochloride salt form enhances solubility and handling in research applications. Copanlisib dihydrochloride is widely used to study PI3K-driven cancers, tumor immunology, and resistance mechanisms.
| CAS Number | 1402152-13-9 |
| Synonyms | 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide;dihydrochloride |
| Molecular Formula | C23H30Cl2N8O4 |
| Purity | ≥95% |
| IUPAC Name | 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide;dihydrochloride |
| InChI | InChI=1S/C23H28N8O4.2ClH/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15;;/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27);2*1H |
| InChIKey | KWVVOPDWPMORCQ-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC2=C3NCCN3C(=NC(=O)C4=CN=C(N=C4)N)N=C21)OCCCN5CCOCC5.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
