Compound 48/80 trihydrochloride

• CAT Number: R067101
• CAS Number: 848035-21-2
• Molecular Formula: C32H48Cl3N3O3
• Molecular Weight: 629.10
• Purity: ≥95%
• Synonyms: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride
• InChI: InChI=1S/C32H45N3O3.3ClH/c1-33-14-11-23-7-9-30(36-4)26(17-23)21-28-19-25(13-16-35-3)20-29(32(28)38-6)22-27-18-24(12-15-34-2)8-10-31(27)37-5;;;/h7-10,17-20,33-35H,11-16,21-22H2,1-6H3;3*1H
• InChIKey: KIAWAQJORBNOIF-UHFFFAOYSA-N
• SMILES: CNCCC1=CC(=C(C=C1)OC)CC2=CC(=CC(=C2OC)CC3=C(C=CC(=C3)CCNC)OC)CCNC.Cl.Cl.Cl

Compound 48/80 trihydrochloride（Cat No.:R067101）is a cationic polymer mixture widely recognized as a potent mast cell degranulator. It induces histamine and serotonin release from mast cells by activating G-protein–coupled receptors, particularly MRGPRX2, triggering allergic and inflammatory responses. Supplied as the trihydrochloride salt, it offers improved solubility and stability for laboratory use. This compound is extensively applied in immunology, allergy, and inflammation research, serving as a standard tool to model mast cell–mediated reactions and to evaluate antihistamines, anti-allergic agents, and signaling pathways linked to hypersensitivity responses.