Compound 48/80

• CAT Number: I045564
• CAS Number: 94724-12-6
• Molecular Formula: C32H45N3O3
• Molecular Weight: 519.72
• Purity: ≥95%
• Synonyms: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine
• InChI: InChI=1S/C32H45N3O3/c1-33-14-11-23-7-9-30(36-4)26(17-23)21-28-19-25(13-16-35-3)20-29(32(28)38-6)22-27-18-24(12-15-34-2)8-10-31(27)37-5/h7-10,17-20,33-35H,11-16,21-22H2,1-6H3
• InChIKey: DXEVTBAWIGXNAW-UHFFFAOYSA-N
• SMILES: CNCCC1=CC(=C(C=C1)OC)CC2=CC(=CC(=C2OC)CC3=C(C=CC(=C3)CCNC)OC)CCNC

Compound 48/80 (Cat No.: I045564) is a synthetic mast cell degranulating agent widely used in immunology and allergy research. By triggering mast cell activation, it promotes the release of histamine, serotonin, and other inflammatory mediators, mimicking allergic and anaphylactic responses. It is commonly employed in animal models to study mast cell biology, hypersensitivity reactions, and inflammatory pathways. Additionally, Compound 48/80 is valuable for screening anti-allergic and anti-inflammatory drugs, providing researchers with a reliable tool for investigating immune regulation and allergic mechanisms.

Reference

[1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.
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[2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124.
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[3]. Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6.
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