Combretastatin A-1

• CAT Number: M004991
• CAS Number: 109971-63-3
• Molecular Formula: C18H20O6
• Molecular Weight: 332.35
• Purity: ≥95%
• Synonyms: 3-methoxy-6-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
• InChI: InChI=1S/C18H20O6/c1-21-13-8-7-12(16(19)17(13)20)6-5-11-9-14(22-2)18(24-4)15(10-11)23-3/h5-10,19-20H,1-4H3/b6-5-
• InChIKey: YUSYSJSHVJULID-WAYWQWQTSA-N
• SMILES: COC1=C(C(=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O)O

Combretastatin A-1 (Cat No.: M004991) is a natural stilbene derivative first isolated from the African bush willow (Combretum caffrum). It belongs to the combretastatin family of vascular-disrupting agents that target tubulin, destabilizing microtubules and blocking mitosis. By collapsing tumor blood vessels, Combretastatin A-1 induces ischemia and necrosis within solid tumors. It has been studied as both a standalone agent and in combination therapies for cancer treatment. Its potent cytotoxic and anti-angiogenic activities make it a valuable lead compound in oncology drug development.

Reference

[1]. Pettit GR, et, al. Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. J Nat Prod. Jan-Feb 1987;50(1):119-31.
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[2]. Mao J, et, al. Combretastatin A-1 phosphate, a microtubule inhibitor, acts on both hepatocellular carcinoma cells and tumor-associated macrophages by inhibiting the Wnt/β-catenin pathway. Cancer Lett. 2016 Sep 28;380(1):134-43.
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[3]. Holwell SE, et, al. Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate. Anticancer Res. Nov-Dec 2002;22(6C):3933-40.
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