COH34 analog 1

• CAT Number: I017885
• CAS Number: 314248-24-3
• Molecular Formula: C18H15NO3S
• Molecular Weight: 325.38
• Purity: ≥95%
• Synonyms: (NE)-N-[(2-hydroxynaphthalen-1-yl)methylidene]-4-methylbenzenesulfonamide
• InChI: InChI=1S/C18H15NO3S/c1-13-6-9-15(10-7-13)23(21,22)19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
• InChIKey: WCYGPLQLYOSVIH-XDHOZWIPSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)/N=C/C2=C(C=CC3=CC=CC=C32)O

COH34 analog 1（Cat No.:I017885）is a potent derivative of COH34, designed as an inhibitor of poly(ADP-ribose) glycohydrolase (PARG), the enzyme responsible for degrading poly(ADP-ribose) chains. By blocking PARG activity, it enhances DNA damage signaling and impairs repair pathways, leading to accumulation of DNA breaks and apoptosis in cancer cells. This compound is a valuable tool for studying DNA damage response, genomic stability, and synthetic lethality. COH34 analog 1 supports research into anticancer strategies that exploit vulnerabilities in DNA repair mechanisms, particularly in tumors with repair deficiencies.