Cocamidopropyl Betaine

  • CAT Number: M002268
  • CAS Number: 61789-40-0
  • Molecular Formula: C19H38N2O3
  • Molecular Weight: 342.52
  • Purity: ≥95%
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Cocamidopropyl betaine (CAPB) (Cat.No:M002268) is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine. CAPB is available as a viscous pale yellow solution and it is used as a surfactant in personal care products. The name reflects that the major part of the molecule, the lauric acid group, is derived from coconut oil. Cocamidopropyl betaine to a significant degree has replaced cocamide DEA.


Catalog Number M002268
CAS Number 61789-40-0
Synonyms

NAXAINE C;NAXAINE CO;1-Propanaminium, 3-amino-N-(carboxymethyl)-N,N-dimethyl-, N-coco acyl derivs., hydroxides, inner salts;NorfoxCapb;1-Propanaminium, 3-amino-N-(carboxymethyl)-N,N-dimethyl-, N-coco acyl derivs., inner salts;COCOACYLAMIDOPROPYLBETAI

Molecular Formula C19H38N2O3
Purity ≥95%
Storage Store at -20℃
IUPAC Name 2-[3-(dodecanoylamino)propyl-dimethylazaniumyl]acetate
InChI InChI=1S/C19H38N2O3/c1-4-5-6-7-8-9-10-11-12-14-18(22)20-15-13-16-21(2,3)17-19(23)24/h4-17H2,1-3H3,(H-,20,22,23,24)
InChIKey MRUAUOIMASANKQ-UHFFFAOYSA-N
SMILES CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-]
Reference

1: Suuronen K, Pesonen M, Aalto-Korte K. Occupational contact allergy to cocamidopropyl betaine and its impurities. Contact Dermatitis. 2012 May;66(5):286-92. doi: 10.1111/j.1600-0536.2011.02036.x. Epub 2012 Feb 24. PubMed PMID: 22364510.<br />
2: Jacob SE, Amini S. Cocamidopropyl betaine. Dermatitis. 2008 May-Jun;19(3):157-60. Review. PubMed PMID: 18627690.<br />
3: Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB). Int J Toxicol. 2012 Jul-Aug;31(4 Suppl):77S-111S. doi: 10.1177/1091581812447202. PubMed PMID: 22869896.<br />
4: Staszak K, Wieczorek D, Michocka K. Effect of Sodium Chloride on the Surface and Wetting Properties of Aqueous Solutions of Cocamidopropyl Betaine. J Surfactants Deterg. 2015;18(2):321-328. Epub 2014 Sep 26. PubMed PMID: 25705107; PubMed Central PMCID: PMC4331618.<br />
5: Welling JD, Mauger TF, Schoenfield LR, Hendershot AJ. Chronic eyelid dermatitis secondary to cocamidopropyl betaine allergy in a patient using baby shampoo eyelid scrubs. JAMA Ophthalmol. 2014 Mar;132(3):357-9. doi: 10.1001/jamaophthalmol.2013.6254. PubMed PMID: 24408863.<br />
6: Schnuch A, Lessmann H, Geier J, Uter W. Is cocamidopropyl betaine a contact allergen? Analysis of network data and short review of the literature. Contact Dermatitis. 2011 Apr;64(4):203-11. doi: 10.1111/j.1600-0536.2010.01863.x. Review. PubMed PMID: 21392028.<br />
7: Yepes-Nu&ntilde;ez JJ, G&oacute;mez Rend&oacute;n FE, Nu&ntilde;ez-Rinta R. Allergic contact dermatitis to cocamidopropyl betaine in Colombia. Allergol Immunopathol (Madr). 2012 Mar-Apr;40(2):126-8. doi: 10.1016/j.aller.2011.02.006. Epub 2011 Apr 22. PubMed PMID: 21514987.

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