COBRATOXIN (Alpha-)

• CAT Number: P000009
• CAS Number: 69344-74-7
• Molecular Formula: C332 H520 N98 O101 S10
• Molecular Weight: 7,821
• Purity: ≥95%
• Solubility: Well in water and saline
• Storage: Stable in dry state.Store in a dark place. Keep the solution at -20 °C.

It is a long chain postsynaptic neurotoxin, antagonist of nicotinic receptor with a high affinity. A 71-amino acid polypeptide with 5 disulfide Bonds, purified from Naja kaouthia snake venom. It is a nicotinic cholinoreceptor antagonist: Kd = 55 pM,homologue of postsynaptically acting toxins.

Reference

– Ishikawa Y. et al., Toxicon (1977). 15:477-488

– Charpentier I. et al., J. of Molecular Recognition (1990). 3:74-81

– Faure G. et al., Biochemistry (1983). 22:2068-2076

– Karlsson E. et al.,/Isolation of the principal neurotoxins of Naja naja subspecies from the asian mainland./ Toxicon (1972). 10:217-225

– Walkinshaw M.D. et al., Proc. Natl. Acad. Sci. USA (1980). 77:2400-2404

– Betzel C. et al., J. Biol. Chem. (1991). 266:21530-21536