Cobomarsen

• CAT Number: I045366
• CAS Number: 1848257-52-2
• Molecular Weight: 4736.00
• Purity: ≥95%

Cobomarsen (Cat No.: I045366) is an investigational antisense oligonucleotide designed to inhibit microRNA-155 (miR-155), an oncogenic microRNA overexpressed in various hematologic malignancies, including cutaneous T-cell lymphoma (CTCL). By blocking miR-155, cobomarsen restores normal gene expression involved in cell cycle regulation and apoptosis, thereby suppressing tumor cell growth and survival. It is administered via intravenous infusion and has shown promising activity in early clinical trials. Cobomarsen represents a novel, targeted therapeutic strategy for treating cancers driven by miR-155 dysregulation.

Reference

[1]. Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.
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[2]. Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.
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