CMPD-39

• CAT Number: I045257
• CAS Number: 2242582-40-5
• Molecular Formula: C26H28FN3O4S
• Molecular Weight: 497.58
• Purity: ≥95%
• Synonyms: N-[(2S)-1-[4-(tert-butylsulfamoyl)anilino]-1-oxo-3-phenylpropan-2-yl]-4-fluorobenzamide
• InChI: InChI=1S/C26H28FN3O4S/c1-26(2,3)30-35(33,34)22-15-13-21(14-16-22)28-25(32)23(17-18-7-5-4-6-8-18)29-24(31)19-9-11-20(27)12-10-19/h4-16,23,30H,17H2,1-3H3,(H,28,32)(H,29,31)/t23-/m0/s1
• InChIKey: NRHPFMQPXSSELC-QHCPKHFHSA-N
• SMILES: CC(C)(C)NS(=O)(=O)C1=CC=C(C=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)C3=CC=C(C=C3)F

CMPD-39（Cat No.:I045257）is a selective, brain-penetrant inhibitor of ubiquitin-specific protease 30 (USP30), a mitochondrial outer membrane–associated deubiquitinase. By blocking USP30 activity, CMPD-39 enhances mitochondrial ubiquitination, promoting mitophagy and improving mitochondrial quality control. This compound is valuable in studying the regulation of mitochondrial turnover and its role in neurodegenerative diseases such as Parkinson’s disease, where defective mitophagy is implicated. CMPD-39’s potency, selectivity, and central nervous system permeability make it a promising tool for exploring therapeutic strategies that target mitochondrial dysfunction and protein homeostasis in age-related and neurodegenerative disorders.