For research use only. Not for therapeutic Use.
CM398（Cat No.:I045081）is a potent and selective antagonist of the Transient Receptor Potential Vanilloid 1 (TRPV1) channel, which plays a key role in pain perception and neurogenic inflammation. By inhibiting TRPV1, CM398 blocks the activation of sensory neurons triggered by heat, protons, and capsaicin, offering analgesic effects without affecting normal sensory function. It has shown efficacy in preclinical models of inflammatory and neuropathic pain. Unlike earlier TRPV1 antagonists, CM398 exhibits an improved safety profile with reduced risk of hyperthermia, making it a promising candidate for non-opioid pain management therapies.
| CAS Number | 1121931-70-1 |
| Synonyms | 1-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-methylbenzimidazol-2-one |
| Molecular Formula | C23H29N3O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-methylbenzimidazol-2-one |
| InChI | InChI=1S/C23H29N3O3/c1-24-19-8-4-5-9-20(19)26(23(24)27)12-7-6-11-25-13-10-17-14-21(28-2)22(29-3)15-18(17)16-25/h4-5,8-9,14-15H,6-7,10-13,16H2,1-3H3 |
| InChIKey | FKMMUKDTVNOKQD-UHFFFAOYSA-N |
| SMILES | CN1C2=CC=CC=C2N(C1=O)CCCCN3CCC4=CC(=C(C=C4C3)OC)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
