For research use only. Not for therapeutic Use.
CM10(CAT: I016819) is a potent and selective small-molecule inhibitor of the aldehyde dehydrogenase 1A (ALDH1A) family, with IC₅₀ values of 1.7 μM (ALDH1A1), 740 nM (ALDH1A2), and 640 nM (ALDH1A3). It shows no inhibitory activity against other ALDH isoforms, highlighting its specificity. In cellular assays, CM10 (12.5–100 μM, 1 h) suppresses ALDEFLUOR activity and preferentially depletes CD133⁺ ovarian cancer stem-like cells (CSCs). Mechanistically, it induces a necroptotic phenotype characterized by cellular and nuclear swelling. With its dual role in regulating metabolism and targeting CSCs, CM10 is a valuable probe for cancer biology and therapeutic development.
| CAS Number | 692269-09-3 |
| Synonyms | 2-prop-2-enyl-6-[[(1-propylbenzimidazol-2-yl)amino]methyl]phenol |
| Molecular Formula | C20H23N3O |
| Purity | ≥95% |
| IUPAC Name | 2-prop-2-enyl-6-[[(1-propylbenzimidazol-2-yl)amino]methyl]phenol |
| InChI | InChI=1S/C20H23N3O/c1-3-8-15-9-7-10-16(19(15)24)14-21-20-22-17-11-5-6-12-18(17)23(20)13-4-2/h3,5-7,9-12,24H,1,4,8,13-14H2,2H3,(H,21,22) |
| InChIKey | ZFHWEWJDCFGRBO-UHFFFAOYSA-N |
| SMILES | CCCN1C2=CC=CC=C2N=C1NCC3=CC=CC(=C3O)CC=C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
