ClpB-IN-1

• CAT Number: I042614
• CAS Number: 1453172-23-0
• Molecular Formula: C14H10N2O2S2
• Molecular Weight: 302.37
• Purity: ≥95%
• Synonyms: 3-(4-hydroxy-3-prop-2-enyl-2-sulfanylidene-1,3-thiazol-5-yl)indol-2-one
• InChI: InChI=1S/C14H10N2O2S2/c1-2-7-16-13(18)11(20-14(16)19)10-8-5-3-4-6-9(8)15-12(10)17/h2-6,18H,1,7H2
• InChIKey: GXJJIBDJRDXPGU-UHFFFAOYSA-N
• SMILES: C=CCN1C(=C(SC1=S)C2=C3C=CC=CC3=NC2=O)O

ClpB-IN-1 (Cat No.: I042614) is a selective inhibitor of ClpB, a bacterial ATP-dependent chaperone protein involved in disaggregating and refolding denatured proteins under stress conditions. By targeting ClpB, ClpB-IN-1 disrupts protein homeostasis in bacteria, impairing their ability to survive heat shock and other stressors. This compound is valuable for studying bacterial proteostasis mechanisms and holds potential as an antimicrobial agent, particularly against heat-shock resistant or persistent bacterial strains. ClpB-IN-1 aids in exploring novel antibacterial targets distinct from traditional antibiotic pathways.

Reference

[1]. Martin I, et, al. Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. J Med Chem. 2013 Sep 26;56(18):7177-89.
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