Clozapine N-oxide dihydrochloride (Cat No.:I015582) is a synthetic ligand widely used in chemogenetics, particularly in DREADD (Designer Receptors Exclusively Activated by Designer Drugs) technology. As an inert metabolite of clozapine, it selectively activates engineered G-protein coupled receptors without significantly interacting with endogenous receptors. This enables precise, reversible control of neuronal activity, allowing researchers to study neural circuits, behavior, and disease models. The dihydrochloride salt form enhances solubility and stability, making it suitable for experimental applications in neuroscience, pharmacology, and systems biology for targeted receptor modulation.