Clozapine

• CAT Number: A000188
• CAS Number: 5786-21-0
• Molecular Formula: C18H19ClN4
• Molecular Weight: 326.80
• Purity: ≥95%
• Synonyms: 5786-21-0; Leponex; Clozapin; CLOZARIL; Fazaclo
• Target: Neuronal Signaling
• Solubility: >14.6mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
• InChI: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChIKey: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42

Clozapine（Cat No.:A000188）is an atypical antipsychotic medication with the molecular formula C18H19ClN4, primarily used to treat treatment-resistant schizophrenia and to reduce the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder. It acts on multiple neurotransmitter receptors, including dopamine D2, serotonin 5-HT2A, and others, helping to manage both positive and negative symptoms of psychosis. Clozapine is known for its efficacy in difficult cases but requires regular blood monitoring due to the risk of agranulocytosis. It is administered orally and is considered a gold standard for refractory psychiatric conditions.

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