For research use only. Not for therapeutic Use.
Clothiapine (Cat No.: R023648) is a dibenzothiazepine-class atypical antipsychotic that acts as a serotonin-dopamine antagonist. It exhibits strong affinity for 5-HT2 receptors and moderate affinity for dopamine D2 receptors, contributing to its antipsychotic, antidepressant, and anxiolytic effects. Clothiapine has been investigated for the treatment of schizophrenia, depression, and other psychiatric disorders, though it is not widely marketed. In research, it serves as a valuable pharmacological tool for studying serotonergic and dopaminergic neurotransmission, receptor pharmacology, and the development of neuropsychiatric therapeutics.
| CAS Number | 2058-52-8 |
| Synonyms | 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine |
| Molecular Formula | C18H18ClN3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3 |
| InChIKey | KAAZGXDPUNNEFN-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=C(C=C4)Cl |
| Reference | [1]. Toren P, et al. Case study: emergence of transient compulsive symptoms during treatment with clothiapine. J Am Acad Child Adolesc Psychiatry. 1995;34(11):1469-1472. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
