CLK1-IN-2

• CAT Number: I042355
• CAS Number: 3029431-68-0
• Molecular Formula: C16H12Cl2N2O2S
• Molecular Weight: 367.25
• Purity: ≥95%
• Synonyms: N’-(3,5-dichlorophenyl)-5-methoxy-1-benzothiophene-2-carbohydrazide
• InChI: InChI=1S/C16H12Cl2N2O2S/c1-22-13-2-3-14-9(4-13)5-15(23-14)16(21)20-19-12-7-10(17)6-11(18)8-12/h2-8,19H,1H3,(H,20,21)
• InChIKey: ZDJFIKFQLKJRBA-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)SC(=C2)C(=O)NNC3=CC(=CC(=C3)Cl)Cl

CLK1-IN-2 (Cat No.: I042355) is a selective small-molecule inhibitor targeting CDC-like kinase 1 (CLK1), a serine/threonine kinase involved in the regulation of alternative mRNA splicing through phosphorylation of SR proteins. By inhibiting CLK1, CLK1-IN-2 modulates gene expression patterns, making it a valuable research tool in studying splicing-related diseases and potential cancer therapies. Its high specificity enables detailed investigation into CLK1’s role in cell cycle control and neurodegenerative disorders. This compound is widely used in biochemical assays and preclinical studies for therapeutic exploration.

Reference

[1]. Dalia S El-Gamil, et al. Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity. Eur J Med Chem. 2022 Dec 15;247:115019.
[Content Brief]