For research use only. Not for therapeutic Use.
CLinDMA（Cat No.:I044131）is a cationic lipid commonly used in the formulation of lipid nanoparticles (LNPs) for the delivery of nucleic acids such as mRNA, siRNA, and DNA. It plays a crucial role in stabilizing LNP structures and facilitating cellular uptake and endosomal escape of genetic material. CLinDMA is particularly valuable in gene therapy and vaccine development, including mRNA-based therapeutics. Its ionizable properties enhance biocompatibility and reduce toxicity, making it ideal for in vivo delivery applications. CLinDMA supports advanced research in nanomedicine, drug delivery systems, and gene-based therapeutic strategies.
| CAS Number | 908860-82-2 |
| Synonyms | 2-[4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]butoxy]-N,N-dimethyl-3-[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine |
| Molecular Formula | C54H97NO3 |
| Purity | ≥95% |
| IUPAC Name | 2-[4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]butoxy]-N,N-dimethyl-3-[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine |
| InChI | InChI=1S/C54H97NO3/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-38-56-43-48(42-55(7)8)58-40-26-25-39-57-47-34-36-53(5)46(41-47)30-31-49-51-33-32-50(45(4)29-27-28-44(2)3)54(51,6)37-35-52(49)53/h13-14,16-17,30,44-45,47-52H,9-12,15,18-29,31-43H2,1-8H3/b14-13-,17-16-/t45-,47+,48?,49+,50-,51+,52+,53+,54-/m1/s1 |
| InChIKey | PGYFLJKHWJVRMC-ZXRZDOCRSA-N |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCCOCC(CN(C)C)OCCCCO[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
