• CAT Number: I002183
  • CAS Number: 167221-71-8
  • Molecular Formula: C21H23Cl2NO6
  • Molecular Weight: 456.32
  • Purity: ≥95%
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Clevidipine Butyrate (Cat No.:I002183) is a dihydropyridine calcium channel inhibitor used to lower blood pressure. Clevidipine has a high degree of vascular and myocardial selectivity, and is rapidly metabolized into inactive substances in the body. Clevidipine has a strong pulse rate-lowering activity and also has a dilating effect on systemic blood vessels and pulmonary blood vessels.

Catalog Number I002183
CAS Number 167221-71-8

5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Molecular Formula


Purity 95%
Target Calcium Channel
Solubility DMSO: 91 mg/mL, H2O: < 1 mg/mL
Storage 2-8°C
IC50 7.1 nM at V(H) = -40 mV
IUPAC Name 5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChI InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3

</br>1:Intravenous Clevidipine for Inducing Hypotensive Challenge During Carotid Balloon Test Occlusion. Tarlov N, Kass-Hout O, Guterman LR, Qureshi AI.J Neurosurg Anesthesiol. 2016 Dec 22. doi: 10.1097/ANA.0000000000000392. [Epub ahead of print] No abstract available. PMID: 28009636 </br>2:Clevidipine Versus Nicardipine for Acute Blood Pressure Reduction in a Neuroscience Intensive Care Population. Finger JR, Kurczewski LM, Brophy GM.Neurocrit Care. 2017 Apr;26(2):167-173. doi: 10.1007/s12028-016-0349-4. PMID: 27995512 </br>3:Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery. Cruz JE, Thomas Z, Lee D, Moskowitz DM, Nemeth J.P T. 2016 Oct;41(10):635-639. PMID: 27757002 Free PMC Article</br>4:Clevidipine-induced Dyspnea Relief in Acute Heart Failure Patients. Stoicea N, Joseph N, Bergese SD.EBioMedicine. 2016 Aug;10:23-4. doi: 10.1016/j.ebiom.2016.07.014. Epub 2016 Jul 16. No abstract available. PMID: 27495792 Free PMC Article</br>5:Comparison of Clevidipine Versus Sodium Nitroprusside for the Treatment of Postoperative Hypertension in Cardiac Surgery Patients. Freiberger NA, Tellor KB, Stevens AM.Hosp Pharm. 2016 Jun;51(6):461-7. doi: 10.1310/hpj5106-461. PMID: 27354747 </br>6:High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure. Dahl GP, Conner GE, Qiu F, Wang J, Spindler E, Campagna JA, Larsson HP.EBioMedicine. 2016 Aug;10:291-7. doi: 10.1016/j.ebiom.2016.06.027. Epub 2016 Jun 22. PMID: 27349457 Free PMC Article</br>7:Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis. Espinosa A, Ripollés-Melchor J, Casans-Francés R, Abad-Gurumeta A, Bergese SD, Zuleta-Alarcon A, López-Timoneda F, Calvo-Vecino JM; Evidence Anesthesia Review Group..PLoS One. 2016 Mar 28;11(3):e0150625. doi: 10.1371/journal.pone.0150625. eCollection 2016. Review. PMID: 27018586 Free PMC Article</br>8:[Simultaneous determination of clevidipine butyrate and its metabolite clevidipine acid in dog blood by liquid chromatography-tandem mass spectrometry]. Wei HH, Gu Y, Liu YP, Wei GL, Chen Y, Liu CX, Si DY.Yao Xue Xue Bao. 2015 Oct;50(10):1290-6. Chinese. PMID: 26837176 </br>9:Structural Analysis and Quantitative Determination of Clevidipine Butyrate Impurities Using an Advanced RP-HPLC Method. Zhou Y, Zhou F, Yan F, Yang F, Yao Y, Zou Q.J Chromatogr Sci. 2016 Mar;54(3):353-60. doi: 10.1093/chromsci/bmv148. Epub 2015 Oct 21. PMID: 26489435 </br>10:The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity in Human Volunteers. Lemkuil BP, Gierl BT, Patel PM, Pearn ML, Nguyen LC, Minokadeh A, Drummond JC.J Neurosurg Anesthesiol. 2016 Oct;28(4):337-40. doi: 10.1097/ANA.0000000000000236. PMID: 26447497

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