Clemizole-d4

• CAT Number: I040208
• Molecular Formula: C19H16D4ClN3
• Molecular Weight: 329.86
• Purity: ≥95%
• Synonyms: 1-[(4-chloro-2,3,5,6-tetradeuteriophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole
• InChI: InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2/i7D,8D,9D,10D
• InChIKey: CJXAEXPPLWQRFR-ULDPCNCHSA-N
• SMILES: C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl

Clemizole-d₄(CAT: I040208) is a deuterium-labeled analog of Clemizole, a known H1 histamine receptor antagonist. In addition to its antihistaminic activity, Clemizole has been identified as a potent inhibitor of hepatitis C virus (HCV) replication, acting through modulation of host-virus interactions. The incorporation of four deuterium atoms enhances its metabolic stability and makes it ideal for use as an internal standard in pharmacokinetic, metabolic, and bioanalytical studies involving Clemizole. Clemizole-d₄ is particularly valuable for tracing and quantifying drug distribution and metabolism in research focused on viral infections and antiviral drug development.