CL2A

• CAT Number: I046109
• CAS Number: 2616704-22-2
• Molecular Formula: C50H79N9O16
• Molecular Weight: 1062.21
• Purity: ≥95%
• Synonyms: N-[[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-[2-[[(2S)-6-amino-1-[4-(hydroxymethyl)anilino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl]-4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxamide
• InChI: InChI=1S/C50H79N9O16/c51-14-2-1-3-44(50(66)54-42-10-6-40(36-60)7-11-42)55-46(62)38-75-37-45(61)52-15-17-67-19-21-69-23-25-71-27-29-73-31-32-74-30-28-72-26-24-70-22-20-68-18-16-58-35-43(56-57-58)33-53-49(65)41-8-4-39(5-9-41)34-59-47(63)12-13-48(59)64/h6-7,10-13,35,39,41,44,60H,1-5,8-9,14-34,36-38,51H2,(H,52,61)(H,53,65)(H,54,66)(H,55,62)/t39?,41?,44-/m0/s1
• InChIKey: CJDCJOXHKQMGGB-DBSIFAAZSA-N
• SMILES: C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)NCC3=CN(N=N3)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COCC(=O)N[C@@H](CCCCN)C(=O)NC4=CC=C(C=C4)CO

CL2A（Cat No.:I046109）is a cleavable linker used in the design of antibody–drug conjugates (ADCs), enabling controlled release of cytotoxic payloads within targeted cells. It is engineered to remain stable in systemic circulation but undergo cleavage in the intracellular environment, often triggered by lysosomal enzymes or acidic pH. This selective release enhances therapeutic efficacy while reducing off-target toxicity. CL2A linkers have been applied in experimental ADCs for oncology research, helping evaluate strategies to improve drug delivery, tumor selectivity, and safety profiles in antibody-guided cancer therapy development.