For research use only. Not for therapeutic Use.
CKK-E12（Cat No.:I044109）is a selective small-molecule inhibitor of casein kinase 1 epsilon (CK1ε), a serine/threonine kinase involved in the regulation of circadian rhythms, Wnt signaling, and cell cycle progression. By inhibiting CK1ε activity, CKK-E12 modulates phosphorylation of key regulatory proteins such as PER (Period circadian proteins) and components of the β-catenin pathway, making it valuable in studies of chronobiology, oncogenesis, and signal transduction. CKK-E12 is commonly used in cancer research and neuroscience to probe CK1ε-dependent mechanisms and supports the development of targeted therapies for circadian and proliferative disorders.
| CAS Number | 1432494-65-9 |
| Synonyms | 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]piperazine-2,5-dione |
| Molecular Formula | C60H120N4O6 |
| Purity | ≥95% |
| IUPAC Name | 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]piperazine-2,5-dione |
| InChI | InChI=1S/C60H120N4O6/c1-5-9-13-17-21-25-29-33-41-53(65)49-63(50-54(66)42-34-30-26-22-18-14-10-6-2)47-39-37-45-57-59(69)62-58(60(70)61-57)46-38-40-48-64(51-55(67)43-35-31-27-23-19-15-11-7-3)52-56(68)44-36-32-28-24-20-16-12-8-4/h53-58,65-68H,5-52H2,1-4H3,(H,61,70)(H,62,69) |
| InChIKey | ZISVTYVLWSZJAL-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCC(CN(CCCCC1C(=O)NC(C(=O)N1)CCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
