CJ-42794- CAS 847728-01-2

CAS No.: 847728-01-2

PubChem Substance ID: 355037281

Inquire CJ-42794 (cas: 847728-01-2 ) online by filling out the inquiry form, we will get back to you within 24 hours!

CJ-42794,847728-01-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I005074
Synonyms:

4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid

Molecular Formula:

C22H17ClFNO4

Molecular Weight:413.8
IC50::8.5 (pKi ) [1]
Description:CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).IC50 value: 8.
Price:Get quote

We would like to match the lowest price on market if possible.

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).
IC50 value: 8.5 (pKi ) [1]
Target: EP4
in vitro: CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor with a mean pA2 value of 8.6. PGE2 inhibits the lipopolysaccharide (LPS)-induced production of tumor necrosis factor α (TNFα) in human whole blood (HWB); CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. [1]
in vivo: CJ-42794 significantly delays the ulcer healing in rats and mice. The expression of VEGF in primary rat gastric fibroblasts was increased by PGE2 or AE1-329 (EP4 agonist), and these responses were both attenuated by coadministration of CJ-42794.[2]

Chem Calculators

© 2017-2022 MuseChem - A division of ArrakisTek Inc. All Rights Reserved.