cis-Tadalafil

• CAT Number: R048518
• CAS Number: 171596-27-3
• Molecular Formula: C22H19N3O4
• Molecular Weight: 389.41
• Purity: ≥95%
• Synonyms: (6R,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1’,2’:1,6]pyrido[3,4-b]indole-1,4-dione; (6R-cis)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-?hexahydro-2-methylpyrazino[1’,2’:1,6]pyrido[3,4-b]indole-1,4-dione; Tadalafil EP
• Target: Phosphodiesterase (PDE)
• Storage: -20°C
• InChI: InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/m0/s1
• InChIKey: WOXKDUGGOYFFRN-HRAATJIYSA-N
• SMILES: CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36

Cis-Tadalafil (Cat No.: R048518) is a stereoisomer of tadalafil, a selective phosphodiesterase type 5 (PDE5) inhibitor used primarily to treat erectile dysfunction and pulmonary arterial hypertension. While the clinically approved form of tadalafil is the trans-isomer, cis-tadalafil differs in spatial configuration, potentially altering its binding affinity and pharmacological profile. It features a complex fused-ring structure and shares the core scaffold of other PDE5 inhibitors. Cis-tadalafil is mainly of interest in research settings to study structure-activity relationships and stereochemical influences on drug action.