Cipepofol

• CAT Number: I028906
• CAS Number: 1637741-58-2
• Molecular Formula: C14H20O
• Molecular Weight: 204.31
• Purity: ≥95%
• Synonyms: 2-[(1R)-1-cyclopropylethyl]-6-propan-2-ylphenol
• InChI: InChI=1S/C14H20O/c1-9(2)12-5-4-6-13(14(12)15)10(3)11-7-8-11/h4-6,9-11,15H,7-8H2,1-3H3/t10-/m1/s1
• InChIKey: BMEARIQHWSVDBS-SNVBAGLBSA-N
• SMILES: CC(C)C1=C(C(=CC=C1)C(C)C2CC2)O

Cipepofol (Cat No.: I028906) is a novel intravenous anesthetic agent structurally related to propofol, developed to provide rapid-onset sedation and anesthesia with improved safety and tolerability. Acting as a positive allosteric modulator of GABA_A receptors, it enhances inhibitory neurotransmission, leading to sedative, hypnotic, and anesthetic effects. Cipepofol has shown favorable pharmacokinetics, reduced cardiovascular and respiratory depression, and rapid recovery profiles in clinical studies. It is under investigation as an alternative to propofol in general anesthesia, sedation, and procedural settings.

Reference

[1]. Ming Lu, et al. Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? Biomed Res Int. 2023 Jan 19:2023:7443226.
[Content Brief]

[2]. Yunzhao Yang, et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front Pharmacol. 2022 Nov 22:13:1037151.
[Content Brief]